How long does it take for tibolone to leave your system?

How long does it take for tibolone to leave your system?

Both hydroxy-metabolites have a half-life of approximately 7 hours, but circulatory levels of the 3α-hydroxy metabo-lite are about 4 times higher than that of the 3β-hydroxy metabolite. These two metabolites are responsible for the estrogenic activity of tibolone.

Is tibolone the same as livial?

Livial tablets contain the active ingredient tibolone, which is a synthetic steroid medicine used for hormone replacement therapy (HRT). It mimics the activity of the female sex hormones in the body.

Can you overdose on tibolone?

If you take too much TIBOLONE SANDOZ (overdose) You may need urgent medical attention. Signs of an overdose may include feeling sick or vomiting. Vaginal bleeding may also occur after a few days.

When is the best time to take tibolone?

Take one 2.5 mg tablet every day. You may take tibolone at whatever time of day you find easiest to remember, but try to take your doses at the same time of day, each day. You can take the tablets before or after meals. You may find it helps to swallow the tablet with a drink of water.

Can you take tibolone every second day?

However studies have shown that half a tablet (1.25mg) can be effective to prevent bone loss and fractures in older women. Many women find 1.25 mg enough to treat their flushes and sweats. It is quite reasonable to start with half a tablet daily but the dose should never exceed one tablet daily.

Does tibolone make you put on weight?

Overall tibolone was well tolerated and climacteric symptoms were relieved within 3-5 weeks. The major side effect was weight gain and/or a tendency to bloating and oedema which occurred in 11.28% of our women.

Does tibolone help anxiety?

In our study, we found that tibolone was superior to placebo in anxiety and Kupperman index scores. In menopausal women, the psychological benefits of HT may occur because of the relief of vasomotor symptoms and a reduction in vaginal dryness, and this is known as the ‘domino effect’ (2).

Does tibolone make you gain weight?

Occasionally women report fluid retention and mild weight gain with tibolone- if this occurs it is reasonable to try taking half a tablet (1.25 mg) each day.

Can tibolone cause stroke?

Stroke. The LIFT study identified a significantly (2·2-times) increased risk of stroke, mostly ischaemic, in tibolone users; risk increased from the first year of treatment. Baseline risk of stroke is strongly age-dependent, and so the absolute risk with tibolone increases with older age.