How is agranulocytosis managed?

How is agranulocytosis managed?

How is agranulocytosis managed?

The treatment of acquired agranulocytosis includes the identification and elimination of drugs or other agents that induce this disorder. Antibiotic medications may also be prescribed if there is a positive blood culture for the presence of bacteria or if a significant local infection develops.

What is the best treatment for neutropenia?

Approaches for treating neutropenia include:

  • Antibiotics for fever.
  • A treatment called granulocyte colony-stimulating factor (G-CSF).
  • Changing medications, if possible, in cases of drug-induced neutropenia.
  • Granulocyte (white blood cell) transfusion (very uncommon)

Which psychotropic medication is associated with agranulocytosis?

Agranulocytosis and neutropenia have been reported in association with the use of most psychotropic medications, including lamotrigine, mirtazapine, quetiapine, and venlafaxine, and the literature includes many reports (a total of 31 cases) of hematologic adverse events associated with the four drugs.

What psych meds cause agranulocytosis?

Of drugs encountered in psychiatry, antipsychotics including clozapine (risk of agranulocytosis approximately 0.8%, predominantly in the first year of treatment) and phenothiazines (chlorpromazine agranulocytosis risk approximately 0.13%), and antiepileptics (notably carbamazepine, neutropenia risk approximately 0.5%) …

How quickly does agranulocytosis occur?

Agranulocytosis usually occurs within the first 2–3 months of treatment (2); however, certain cases have demonstrated that agranulocytosis may occur following long-term treatment (3).

Can you cure agranulocytosis?

Agranulocytosis is treatable with medication, but the outlook varies from person to person. Adults over 65 are more likely to experience complications such as sepsis. Agranulocytosis can cause severe problems in people who have other health conditions, such as kidney disease, heart disease or breathing problems.

How do you know if you have agranulocytosis?

What are the symptoms of agranulocytosis?

  1. Fever and chills.
  2. Faster heart rate and breathing.
  3. Sudden low blood pressure (hypotension), which can make you feel lightheaded or weak.
  4. Muscle weakness and fatigue.
  5. Sore mouth and throat and bleeding, inflamed gums.

What medications can cause agranulocytosis?

Drugs that can cause agranulocytosis include:

  • antithyroid medications, such as carbimazole and methimazole (Tapazole)
  • anti-inflammatory medications, such as sulfasalazine (Azulfidine), dipyrone (Metamizole), and nonsteroidal anti-inflammatory drugs (NSAIDs)
  • antipsychotics, such as clozapine (Clozaril)

Which drugs can cause agranulocytosis?