Can I take Effexor with tamoxifen?

Can I take Effexor with tamoxifen?

SAN ANTONIO — The antidepressant venlafaxine (Effexor), often given to breast cancer patients to treat the hot flashes associated with tamoxifen therapy, might reduce the effectiveness of the drug, a researcher said here.

Do antidepressants reduce the effectiveness of tamoxifen?

A study found that women taking the antidepressant Paxil (chemical name: paroxitene) at the same time as the hormonal therapy medicine tamoxifen were more likely to die from breast cancer than women taking tamoxifen who never took Paxil.

Which antidepressant is best with tamoxifen?

The major concern is that some antidepressants inhibit the function of the CYP2D6 enzyme (described above) which is required for the conversion of tamoxifen to its active form. Examples of strong CYP2D6 inhibitors are bupropion (Wellbutrin), fluoxetine (Prozac), and paroxetine (Paxil).

Is depression a side effect of tamoxifen?

Tamoxifen is known to trigger depressive symptoms as a result of its anti-estrogenic activity.

Is 10 mg of tamoxifen as effective as 20mg?

(18) demonstrate that lower doses of tamoxifen (5 mg/day and 10 mg/day) are less effective than the 20 mg/day dose at reducing normal breast cell proliferation, as measured by mitotic index. These data argue against using lower doses of tamoxifen for breast cancer prevention.

What is the best antidepressant to take with tamoxifen?

Does CBD interfere with tamoxifen?

It was postulated that CBD may diminish tamoxifen metabolism by CYP3A4 and 2D6 to form active metabolite endoxifen, which exerts the anticancer benefits.

What antidepressant does not interfere with tamoxifen?

Examples of strong CYP2D6 inhibitors are bupropion (Wellbutrin), fluoxetine (Prozac), and paroxetine (Paxil). Other SSRI medications, such as citalopram (Celexa), escitalopram (Lexapro), venlafaxine (Effexor) and sertraline (Zoloft) are considered to be less potent inhibitors of CYP2D6.

Can I take turmeric while taking tamoxifen?

Therefore, if you are on tamoxifen it may be best to avoid turmeric and curcumin (particularly in concentrated supplement form), as it can lower the concentration of endoxifen in the body such that it interferes with the therapeutic impact of the drug.