What are the factors which affect absorption?

What are the factors which affect absorption?

What are the factors which affect absorption?

Absorption: depends on drug pKa and whether its an acidic or basic drug, GI ph influences drug absorption by determining amount of drug that would exist in unionised form at the site of absorption.

What factors affect drug absorption?

Drug absorption depends on the lipid solubility of the drug, its formulation and the route of administration. A drug needs to be lipid soluble to penetrate membranes unless there is an active transport system or it is so small that it can pass through the aqueous channels in the membrane.

What kind of factors affect the absorption of oral medication?

Solubility and permeability are considered as the major physicochemical factor that affect the rate and extent of oral drug absorption, moreover other physicochemical properties always show their effects to drug absorption via affecting solubility and permeability.

What are the factors that affect absorption of water?

Factors affecting absorption of water

  • Available soil water.
  • Concentration of soil solution.
  • Soil air.
  • Soil temperature.
  • Transpiration.
  • Absorbing root systems.
  • Metabolism.

What are the physicochemical factors affecting drug absorption?

Physicochemical Factors Affecting Drug Absorption

  • Drug solubility & dissolution rate.
  • Particle Size and Effective Surface Area of the Drug.
  • Polymorphism and Amorphism.
  • Hydrates/Solvates (Pseudopolymorphism)
  • Salt form of the drug.
  • Drug pKa and Lipophilicity and GI pH—pH Partition Hypothesis.

What are the factors affecting stomatal movement?

There are a number of factors which influence stomatal movements. These include light, temperature, potassium chloride, organic acid, carbondioxide concentration, water and abscissic acid.

Which tissue is responsible for absorption of water?

In the root, the epidermis aids in absorption of water and minerals. Root hairs, which are extensions of root epidermal cells, increase the surface area of the root, greatly contributing to the absorption of water and minerals.

What are physicochemical factors?

Physicochemical factors (physical and chemical conditions) are abiotic factors that affect the environment for geomicrobes. Examples of physicochemical factors are: Temperature. pH.

Which are the two rate determining step of drug absorption when given orally?

Q10: Which are the two rate-determining step of drug absorption when given orally? Explanation: The two critical slower rate-determining processes in the absorption of orally administered drugs are the rate of dissolution and rate of the solute or the drug permeation through the cell membrane or biomembrane.

What are the four stages of pharmacokinetics?

Think of pharmacokinetics as a drug’s journey through the body, during which it passes through four different phases: absorption, distribution, metabolism, and excretion (ADME). The four steps are: Absorption: Describes how the drug moves from the site of administration to the site of action.

What is the first phase of drug action?

The pharmaceutic phase (dissolution) is the first phase of drug action. In the gastrointestinal (GI) tract, drugs need to be in solution so they can be absorbed. A drug in solid form (tablet or capsule) must disintegrate into small particles to dissolve into a liquid, a process known as dissolution.

Which drug has a higher absorption rate after a fatty meal?

Piperaquine (PQ) is an antimalarial drug whose high lipid solubility suggests that its absorption can be increased by a high-fat meal.

Why does gastric emptying affect drug absorption?

The rate of gastric emptying affects all drugs, even those which are well absorbed in the stomach. This is because of the fact that the small intestine has a significantly larger surface area and contributes the most to drug absorption. Ergo, gastric motility is a major determinant of oral drug absorption.