Can allopurinol cause chills?

Can allopurinol cause chills?

Therefore, treatment with ZYLOPRIM (allopurinol) should be discontinued immediately if a rash develops (see WARNINGS). Some patients with the most severe reaction also had fever, chills, arthralgias, cholestatic jaundice, eosinophilia and mild leukocytosis or leukopenia.

Can allopurinol cause neuropathy?

A patient experienced an axonomyelinic peripheral neuropathy during a long-term allopurinol treatment. The symptoms and signs regressed after drug withdrawal, and the nerve conduction velocities and distal latencies improved. The incidence of allopurinol-induced peripheral neuropathy is very low.

Does allopurinol affect my immune system?

… Allopurinol also reduces ROS levels in T cells and inhibits their functions [243]. Allopurinol attenuates OVAinduced immune reactions through deactivating helper T cells in BALB/c mice [244] .

Do you have to wean off allopurinol?

What will happen if I stop taking it? If you stop allopurinol treatment suddenly, there is a high risk that gout may get worse or you will get serious side effects. Only stop taking allopurinol if a doctor tells you to. A doctor will help you to reduce your dose slowly so you do not get serious side effects.

What are the side effects of stopping allopurinol?

If you stop taking the drug suddenly or don’t take it at all: The uric acid levels in your blood or urine will stay high. If you have gout or kidney stones, you’ll still have symptoms of your condition.

Is allopurinol hard on your liver?

Allopurinol is a xanthine oxidase inhibitor and a widely used medication for gout. Allopurinol is a rare but well known cause of acute liver injury that has features of a hypersensitivity reaction and can be severe and even fatal.

What happens if you suddenly stop taking allopurinol?

If you stop allopurinol treatment suddenly, there is a high risk that gout may get worse or you will get serious side effects. Only stop taking allopurinol if a doctor tells you to. A doctor will help you to reduce your dose slowly so you do not get serious side effects.