What is hereditary nephritis?
What is hereditary nephritis?
What is hereditary nephritis?
(Hereditary Nephritis) Alport syndrome is a hereditary (genetic) disorder that results in glomerulonephritis in which kidney function is poor, blood is present in the urine, and deafness and eye abnormalities sometimes occur.
What is the life expectancy of someone with Alport syndrome?
Prognosis of Alport syndrome Most men with Alport syndrome reach end-stage kidney disease and kidney failure by their 40s or 50s, which can reduce lifespan if not managed with dialysis or a kidney transplant. Most women with Alport syndrome have a normal lifespan.
Can you inherit nephritis?
Hereditary nephritis is usually caused by a defective gene on the X chromosome (female sex chromosome), but it sometimes results from an abnormal gene on a nonsex (autosomal) chromosome. Other factors influence how severe the disorder is in a person who has the defective gene.
Is Alport syndrome painful?
Corneal erosion in which there is loss of the outer layer of the covering of the eyeball, leading to pain, itching, or redness of the eye, or blurred vision. Abnormal coloring of the retina, a condition called dot-and-fleck retinopathy. It doesn’t cause vision problems, but can help diagnose Alport syndrome.
Can a parent pass on a mutation in a kidney cell to his child?
Because of this, it is unlikely that parents or children of the affected person will have the disease. (If a parent or child has one copy of the gene with the mutation, they almost always will have a normal copy of the gene as well). An example is Autosomal Recessive Polycystic Kidney Disease.
How does Alport cause kidney failure?
Alport syndrome is a disease that damages the tiny blood vessels in your kidneys. It can lead to kidney disease and kidney failure. It can also cause hearing loss and problems within the eyes. Alport syndrome causes damage to your kidneys by attacking the glomeruli.
Is Alport syndrome fatal?
Women affected by Alport syndrome generally have a normal lifespan. Typically, the only symptom experienced by female patients is hematuria or the presence of blood in the urine. In extreme instances, elevated blood pressure, swelling, and hearing loss may arise as complications during pregnancy.