What are the causes of Bence Jones proteinuria?

What are the causes of Bence Jones proteinuria?

What are the causes of Bence Jones proteinuria?

They are found in urine as a result of decreased kidney filtration capabilities due to kidney failure, sometimes induced by hypercalcemia from the calcium released as the bones are destroyed or from the light chains themselves.

What is Bence Jones proteinuria associated with?

The Bence-Jones protein urine test is used most often to diagnose and check on multiple myeloma, a type of cancer. Or an abnormal Bence-Jones test result may mean you have a type of malignant lymphoma. These are cancers of the lymphatic system. Multiple myeloma is a type of blood cancer that affects plasma cells.

What is the indication when you have positive result for Bence Jones protein determination?

Bence Jones proteins are not normally found in urine, so a positive test indicates that you probably have multiple myeloma. Other kinds of cancer may also be associated with a positive result. An abnormal test may indicate other types of cancer including lymphoma, chronic lymphocytic leukemia, and macroglobulinemia.

Which protein increases multiple myeloma?

Albumin is the most abundant protein in the blood. When myeloma is active, levels of a chemical messenger in the blood called interleukin-6 (IL-6) are elevated. IL-6 blocks production of albumin, so low albumin levels can signal more aggressive myeloma.

What is another name for Bence Jones protein?

Healthy urine does not contain Bence Jones protein, so its presence is an indication of a health problem. Other names for this test include urine protein electrophoresis (UPEP), urine immunofixation electrophoresis, or immunoassay for free light chains.

How do you take Bence Jones protein?

The Bence Jones protein urine test is a 24-hour test. A person will need to collect all the urine they pass over a 24-hour period, as the components of urine change over the course of the day. The healthcare team will provide a container for collection.

Does multiple myeloma cause foamy urine?

When excreted in large amounts, the Bence Jones proteins (light chains) can sometimes make the urine appear foamy, and can cause injury to the kidneys and kidney failure (see Blood and Urine Tests on page 12).