What drug class is acarbose in?
What drug class is acarbose in?
Acarbose belongs to a class of drugs called alpha-glucosidase inhibitors. It works by slowing the action of certain enzymes that break food down into sugars. This slows down digestion of carbohydrates to keep your blood sugar from rising very high after you eat.
What is the function of acarbose?
Acarbose works by slowing the action of certain chemicals that break down food to release glucose (sugar) into your blood. Slowing food digestion helps keep blood glucose from rising very high after meals.
Is acarbose an insulin?
Background: Acarbose is an oral antidiabetic mainly acting on postprandial blood glucose, inhibiting alphaglucosidase. Through this mechanism, it could improve the peripheral insulin sensitivity and/or increase the insulin secretion.
Is acarbose a pill?
Precose (acarbose tablets) is an oral alpha-glucosidase inhibitor used to treat type 2 diabetes. Precose is sometimes used in combination with insulin or other diabetes medications you take by mouth. Precose is available in generic form.
Who should not use acarbose?
Acarbose is not approved for use by anyone younger than 18 years old.
Can you gain weight on acarbose?
After 26 weeks, completed by 37 subjects in the acarbose group and by 38 subjects in the placebo group, a small weight regain of 0.6 kg was documented in the latter, whereas no weight increase was observed under acarbose treatment (p = 0.38, analysis of covariance with initial body weight as covariable).
Why is acarbose not used?
Acarbose may increase hypoglycemic risk when combined with other anti-diabetic agents that cause hypoglycemia. Digestive enzymes, including amylase, lipase, and protease, may decrease the effectiveness of acarbose. Therapy requires monitoring with other agents that affect blood glucose concentrations.
Can you take acarbose and metformin together?
Acarbose in combination with metformin thus has the potential to delay diabetes complications through improvement of metabolic control. There was also a favorable effect on fasting blood glucose levels.
Will acarbose help me lose weight?
Acarbose, especially in combination with the low calorie diet and exercise, seems to lose weight effectively in obese and overweight patients in communities that have a high carbohydrate intake (like Persian diet).
What happens if you take acarbose without food?
However, low blood sugar can occur if you take acarbose with another type of diabetes medicine, delay or miss a meal or snack, exercise more than usual, drink alcohol, or cannot eat because of nausea or vomiting.
Is acarbose better than metformin?
Previous randomized clinical trials demonstrated that acarbose is as effective as metformin for glycemic control (11–14). Furthermore, in the STOP-NIDDM study, acarbose treatment was shown to prevent 49% of cardiovascular events in patients with impaired glucose tolerance (IGT) (15).
Is acarbose the same as metformin?
Conclusion. The glucose lowering effects of metformin monotherapy and acarbose monotherapy are the same by direct comparison, while metformin is a little better by indirect comparison. This implies that the effect of metformin is at least as good as acarbose’s.
Does acarbose affect the kidneys?
Background: Acarbose has been deemed contraindicated in diabetic patients with chronic kidney disease (CKD) or end-stage renal disease (ESRD), but such use is not uncommon.
Can you take metformin and acarbose together?
Can acarbose cause weight loss?
Conclusion: In obese individuals who undergo a hypocaloric diet and achieve a substantial loss of body weight, acarbose treatment provides only a very modest, not significant benefit to stabilise weight reduction. Thus, acarbose is not a useful adjunct to improve weight maintenance in obese subjects after weight loss.
Can I take acarbose with metformin?
Is acarbose a good drug?
Acarbose is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems.
Does acarbose affect liver?
Introduction. Acarbose is an alpha glucosidase inhibitor which decreases intestinal absorption of carbohydrates and is used as an adjunctive therapy in the management of type 2 diabetes. Acarbose has been linked to rare instances of clinically apparent acute liver injury.
Is acarbose a controlled substance?
Acarbose is used in the treatment of diabetes, type 2 and belongs to the drug class alpha-glucosidase inhibitors. There is no proven risk in humans during pregnancy. Acarbose 50 mg is not a controlled substance under the Controlled Substances Act (CSA).
What is acarbose pharmacology?
Acarbose delays digestion of complex carbohydrates and disaccharides to absorbable monosaccharides, by reversibly inhibiting alpha-glucosidases within the intestinal brush border, thereby attenuating postprandial blood glucose peaks.
Can acarbose cause weight gain?
What’s the generic name for acarbose?
What is the side effect of acarbose?
Common side effects may include: stomach discomfort, gas, bloating; mild diarrhea; or. mild skin rash or itching.
What kind of drug is Acarbose used for?
From Wikipedia, the free encyclopedia Acarbose (INN) is an anti-diabetic drug used to treat diabetes mellitus type 2 and, in some countries, prediabetes. It is a generic sold in Europe and China as Glucobay (Bayer AG), in North America as Precose (Bayer Pharmaceuticals), and in Canada as Prandase (Bayer AG).
Is there a generic version of acarbose in the US?
Acarbose. Acarbose ( INN) is an anti-diabetic drug used to treat diabetes mellitus type 2 and, in some countries, prediabetes. It is a generic sold in Europe and China as Glucobay ( Bayer AG ), in North America as Precose ( Bayer Pharmaceuticals ), and in Canada as Prandase ( Bayer AG ).
Where does acarbose take place in the body?
Acarbose acts locally in the gastrointestinal tract on the surface of enterocytes. Only 2% of an oral acarbose dose is systemically absorbed, with a plasma half-life of 2 h. Acarbose is metabolized by the intestinal microbial flora and digestive enzymes and excreted in the stool.
Which is a reversible enzyme inhibitor of acarbose?
Acarbose is a saccharide which competes with oligosaccharides for the binding sites on the intestinal glucosidase enzymes such as sucrase and maltase. As acarbose has a high affinity for the binding sites, it acts as a reversible enzyme inhibitor.
Are there any clinical studies of acarbose use?
No clinical studies exist establishing conclusive evidence of macrovascular risk reduction with acarbose or any other anti-diabetic drug When diabetic patients are exposed to stress such as fever, trauma, infection, or surgery, a temporary loss of control of blood glucose may occur; at such times, temporary insulin therapy may be necessary
Which is the least inhibited enzyme in acarbose?
The inhibitory effect of acarbose varies according to which enzymes are involved; from most to least inhibited are glucoamylase, sucrase, maltase, and isomaltase. Lactase is not affected by acarbose. Therapeutic Effects Acarbose reduces blood sugar by interfering with carbohydrate absorption from the GI tract. Uses
Are there any side effects when taking acarbose alone?
Because of its mechanism of action, Acarbose when administered alone should not cause hypoglycemia in the fasted or postprandial state. Sulfonylurea agents or insulin may cause hypoglycemia.
How does acarbose affect the absorption of sugars?
It inhibits or delays the absorption of sugars from the intestinal tract. The inhibitory effect of acarbose varies according to which enzymes are involved; from most to least inhibited are glucoamylase, sucrase, maltase, and isomaltase. Lactase is not affected by acarbose. Therapeutic Effects