What is APMPPE eye disease?

What is APMPPE eye disease?

What is APMPPE eye disease?

Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a rare eye disorder of unknown (idiopathic) cause. The disorder is characterized by the impairment of central vision in one eye (unilateral) but, within a few days, the second eye may also become affected (bilateral).

Is APMPPE an autoimmune disease?

The syndrome of APMPPE has also been associated with other systemic autoimmune diseases such as necrotizing vasculitis,21 Wegener granulomatosis,22 cerebral vasculitis,23 polyarteritis nodosa,24 and ulcerative colitis.

What is Ampiginous Choroiditis?

Ampiginous choroiditis is a primary inflammatory choriocapillaropathy with characteristics of both acute posterior multifocal placoid pigment epitheliopathy and serpiginous choroiditis.

What is relentless Placoid Chorioretinitis?

Relentless placoid chorioretinitis (RPC) is characterized by retinal lesions similar in clinical and angiographic appearance to acute posterior multifocal pigment placoid epitheliopathy (APMPPE) and serpiginous choroidopathy but differing in its widespread distribution, the numerous lesions typically seen, and the …

What is Pachychoroid pigment Epitheliopathy?

Pachychoroid Pigment Epitheliopathy PPE is thought to represent a form fruste or precursor of CSCR, as it has features of retinal pigment epithelium disturbances similar to CSCR but without clinical or imaging evidence of acute or chronic subretinal fluid.

What is acute retinal pigment Epitheliitis?

Acute retinal pigment epitheliitis is an infrequently described macular disorder of unknown cause that affects healthy young adults. Acute symptoms include either reduced visual acuity or central scotoma. Ophthalmoscopy discloses discrete pigment clumps with surrounding hypopigmented halos in the center of the macula.

What is Pachydrusen?

While drusen is thought to be diagnostic of AMD, the entity pachydrusen was recently coined by Rick Spaide in 2018 to describe drusenoid lesions, large size of >125 μm and solitary, in the context of a thickened choroid and distinct from the typical soft drusen of AMD [3].

What is pattern dystrophy?

Pattern dystrophy is the umbrella term for a group of retinal conditions. All of them cause a build-up of waste material called lipofuscin, which causes damage to tissue in the eye. Different dystrophies cause different patterns of damage, which might look like egg yolks, butterflies or knotted fishing nets.

Is MEWDS bilateral?

MEWDS is typically a unilateral entity, with bilaterality and recurrences being unusual for this disease. We report a rare bilateral presentation of MEWDS and highlight the utility of multimodal imaging in diagnosing the disease and revealing lesions that may not be seen on clinical examination alone.

What is solar retinopathy?

Solar retinopathy (also known as, photic retinopathy, foveomacular retinitis, solar retinitis, and eclipse retinopathy) refers to a photochemical toxicity and resultant injury to retinal tissues, usually occurring at the fovea.

What is reticular Pseudodrusen?

Reticular pseudodrusen (RPD), also known as subretinal drusenoid deposits, represent a morphological change to the retina distinct from other subtypes of drusen by being located above the level of the retinal pigment epithelium.

Where are Drusens located?

Drusen are focal deposits of extracellular debris located between the basal lamina of the retinal pigment epithelium (RPE) and the inner collagenous layer of Bruch membrane found in normal aged human eyes and in eyes with age-related macular degeneration (AMD).

Can you go blind from pattern dystrophy?

Patients older than 70 years had the most extensive signs of pattern dystrophy and also had the poorest visual acuity, three of these patients were legally blind. Dr. Klein said that visual loss in PD is directly correlated to dystrophic progression to the macula.