Who should not take dapsone?
Who should not take dapsone?
If you know that you are allergic to dapsone, or have had serious reactions to the sulphonamide group of medicines, you must not take dapsone. The dose of dapsone may need to be lower than usual if you have a heart or lung disease, have a condition called G6PD deficiency (see below) or if you are anaemic.
What is the side effects of clofazimine?
COMMON side effects
- discoloration of the eyelid.
- tear discoloration.
- irritation of the stomach or intestines.
- discolored sweat.
- a skin rash.
- decreased appetite.
- sputum discoloration.
Is clofazimine used for TB?
Clofazimine recently moved from group 5 to group B of drugs that are used to treat MDR-TB. This drug belongs to the riminophenazine class, which has lipophilic characteristics and was previously discovered to treat TB and approved for leprosy.
Is clofazimine safe in pregnancy?
There are no controlled data in human pregnancy. Skin pigmentation has been noted in infants born to women treated with clofazimine during pregnancy. Clofazimine is only recommended during pregnancy when benefit outweighs risk.
What happens if I stop taking dapsone?
If you stop taking this medicine too soon, your symptoms may return. This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses.
What are the side effects of rifampicin?
Rifampin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- temporary discoloration (yellow, reddish-orange, or brown color) of your skin, teeth, saliva, urine, stool, sweat, and tears)
- lack of coordination.
Is clofazimine an antibiotic?
Clofazimine, originally described in 1957, is the prototype riminophenazine antibiotic. The primary clinical application of clofazimine since 1962 has been in the treatment of multibacillary leprosy as a component of the WHO-recommended triple drug regimen.
What is clofazimine used for?
Clofazimine is used together with other medicines to treat a form of leprosy (also known as Hansen’s disease), called lepromatous leprosy, including dapsone-resistant lepromatous leprosy, and lepromatous leprosy complicated by erythema nodosum leprosum.
Can leprosy be transmitted from mother to child?
Hansen’s disease is also not passed on from a mother to her unborn baby during pregnancy and it is also not spread through sexual contact.
How long does dapsone stay in your body?
The drug is also N-hydroxylated in the liver which product is responsible for the hemodynamic adverse effects. Its half life is long, 10-50 h and the time to reach plateau is at least 8 days. The drug has been used for other skin disorders also.
Is Rifampin hard on your kidneys?
Knowledge of the toxicity profile is important. Hepatotoxicity is a well-known side effect of Rifampicin necessitating regular liver function monitoring during therapy. Acute kidney injury (AKI) is a relatively rare complication, usually resulting from allergic interstitial nephritis (AIN).
What type of antibiotic is clofazimine?
Clofazimine, a lipophilic riminophenazine antibiotic, possesses both antimycobacterial and anti-inflammatory activities.
Is clofazimine a dye?
Clofazimine is a phenazine dye with anti-mycobacterial and anti-inflammatory activities.
Why was lamprene discontinued?
Clofazimine was discontinued because of gastrointestinal intolerance in 1 of the 5 patients.
How long can you be on dapsone?
You may have to take it every day for as long as 3 years or more, or for life. If you stop taking this medicine too soon, your symptoms may return.