Why do I have recurring malaria?

Why do I have recurring malaria?

Why do I have recurring malaria?

The recurrence in patients with malaria can be caused by reinfection from a new mosquito bite, recrudescence, or relapse [5]. Relapse occurs in P. vivax and P. ovale infections through the activation of hypnozoites in the human liver.

What causes malaria flare ups?

Malaria spreads when a mosquito becomes infected with the disease after biting an infected person, and the infected mosquito then bites a noninfected person. The malaria parasites enter that person’s bloodstream and travel to the liver. When the parasites mature, they leave the liver and infect red blood cells.

How is recurrent malaria treated?

Currently, primaquine is the only treatment available to prevent the relapse of Plasmodium vivax malaria. However, as per the primaquine label and WHO recommendations, it is administered once daily for 14 days – a regimen that is hard for patients to comply with, meaning that many are not cured.

How many times can malaria relapse?

In temperate climes the interval from primary infection to relapse is often long (circa 9 months), while in tropical climes relapses occur frequently at short intervals (3–4 weeks after treatment with rapidly eliminated antimalarial drugs)3,4.

Can you be reinfected with malaria?

The malaria parasite is not in an infected person’s saliva and it is not passed on from one person to another. The only way you can catch malaria from a person is through blood transfusions or organ transplants.

Which malaria can relapse?

Plasmodium vivax is the most geographically widespread cause of human malaria, with an estimated 2.5 billion people at risk of infection1. Vivax malaria is characterised by its ability to relapse following activation of dormant liver-stage parasites called hypnozoites.

Which stage of malarial parasite is responsible for relapse?

On the fusion of macrogamete and microgamete, the zygote develops which attaches to the gut lining of mosquitoes. On maturation of the oocyte, Sporozoite is released in salivary glands of mosquitoes. Therefore, Hypnozoite is responsible for relapse of malarial symptoms.