Does gender matter in cystic fibrosis?

Does gender matter in cystic fibrosis?

Regarding gender, there is evidence to suggest that females with CF have a slightly worse prognosis, with a median mortality rate of 4 years less than males until the age of 20 beyond which male and female mortality rates are comparable [2], [3].

Who is most likely to be affected by cystic fibrosis?

The most affected group is Caucasians of northern European ancestry. About 30,000 people in the United States have cystic fibrosis. The disease affects about 1 in 2,500 to 3,500 white newborns. It’s not as common in other ethnic groups.

Can males with CF reproduce?

Even though the vas deferens is missing, the sperm are not. In fact, sperm production in the testicles is normal in 90 percent of men with CF and CBAVD, meaning that most men with CF can still have biological children through assisted reproductive technology (ART).

Does cystic fibrosis skip a generation?

A person can be a CF carrier even though CF disease has not occurred in the family for many generations. This is because a person who is a CF carrier must have a child with someone else who is also a CF carrier and both of them have to pass the abnormal gene to the child.

How old is the oldest person with CF?

Senior citizens with cystic fibrosis Thanks to advances in DNA testing, doctors are identifying more and more people with CF for the first time well into their 50s, 60s, and 70s. The oldest person diagnosed with CF for the first time in the U.S. was 82, in Ireland was 76, and in the United Kingdom was 79.

Is there a gender disparity in cystic fibrosis?

Background: Cystic fibrosis (CF) is a common life-shortening genetic disease in which women have been described to have worse outcomes than males, particularly in response to respiratory infections with Pseudomonas aeruginosa. However, as advancements in therapies have improved life expectancy, this gender disparity has been challenged.

How does cystic fibrosis affect men and women?

The genetic mutation for cystic fibrosis occurs on chromosome 7 and is not impacted by gender. The severity of symptoms related to cystic fibrosis, however, does vary in men and women. In particular, girls with cystic fibrosis have more difficulty with meeting growth milestones and experience more lung-related problems compared to boys.

How does gender affect the risk of CF?

Female gender proved to be a significant risk factor for death (hazard ratio 2.22, 95% CI 1.79-2.77), despite accounting for variables known to influence CF mortality. Women were also found to become colonized earlier with several bacteria and to have worse outcomes with common CF pathogens.

How does CF affect the life expectancy of women?

Conclusions: CF women continue to have a shortened life expectancy relative to men despite accounting for key CF-related comorbidities. Women also become colonized with certain common CF pathogens earlier than men and show a decreased life expectancy in the setting of respiratory infections.

Background: Cystic fibrosis (CF) is a common life-shortening genetic disease in which women have been described to have worse outcomes than males, particularly in response to respiratory infections with Pseudomonas aeruginosa. However, as advancements in therapies have improved life expectancy, this gender disparity has been challenged.

The genetic mutation for cystic fibrosis occurs on chromosome 7 and is not impacted by gender. The severity of symptoms related to cystic fibrosis, however, does vary in men and women. In particular, girls with cystic fibrosis have more difficulty with meeting growth milestones and experience more lung-related problems compared to boys.

Female gender proved to be a significant risk factor for death (hazard ratio 2.22, 95% CI 1.79-2.77), despite accounting for variables known to influence CF mortality. Women were also found to become colonized earlier with several bacteria and to have worse outcomes with common CF pathogens.

Can a child be born with cystic fibrosis?

Cystic fibrosis (CF) is a genetic disease. This means that CF is inherited. A child will be born with CF only if two CF genes are inherited – one from the mother and one from the father. A person who has only one CF gene is healthy and said to be a “carrier” of the disease.