# What are the chances of a person with cystic fibrosis passing it to their offspring?

## What are the chances of a person with cystic fibrosis passing it to their offspring?

CF carriers can pass their copy of the CFTR gene mutation to their children. Each time two CF carriers have a child together, the chances are: 25 percent (1 in 4) the child will have CF. 50 percent (1 in 2) the child will be a carrier but will not have CF.

## Can you be heterozygous for cystic fibrosis?

The Cystic Fibrosis Gene A person with CF inherits two mutated copies of the CFTR gene. These mutations can either be homozygous, the same, or heterozygous, different mutations. The most common mutation is delta F508, accounting for approximately 70% of all mutations.

Can a child with cystic fibrosis have normal genes?

There is a 1-in-4 chance (25% of the time) the child will receive non-CF normal genes from each parent. When this happens, the child cannot have CF disease and is not a CF carrier.

### What happens if both parents have a CF gene mutation?

What if both parents have a CF gene mutation? If both you and your partner are found to be CF carriers, then with each pregnancy there is a one in four (25 percent) chance of having a child with CF or three in four (75 percent) chance of having a child without CF.

### What are the odds of being a carrier of cystic fibrosis?

On the other hand, if one of your parents is a carrier and the other has CF, you stand a 50/50 chance of either having CF or being a carrier. Unfortunately, there is nothing a parent can do to influence the odds of inheritance one way or the other.

Is it possible to have more than one child with CF?

Some parents think that if they have had 1 child with CF, their other children will be born without the disease. This is not always true. With every pregnancy, parents who both carry the CF gene will always have a 1-in-4 (25%) chance of having a child with CF. For example, the chance of having a girl is 1-in-2 or 50%.

There is a 1-in-4 chance (25% of the time) the child will receive non-CF normal genes from each parent. When this happens, the child cannot have CF disease and is not a CF carrier.

## What are the chances of not having cystic fibrosis?

If both parents are carriers, a child has: a two-in-four chance of being a carrier, like their parents, but not having the disease; and a one-in-four chance of being completely free of the condition – neither having cystic fibrosis nor being a carrier of the faulty CF gene.

What if both parents have a CF gene mutation? If both you and your partner are found to be CF carriers, then with each pregnancy there is a one in four (25 percent) chance of having a child with CF or three in four (75 percent) chance of having a child without CF.

Some parents think that if they have had 1 child with CF, their other children will be born without the disease. This is not always true. With every pregnancy, parents who both carry the CF gene will always have a 1-in-4 (25%) chance of having a child with CF. For example, the chance of having a girl is 1-in-2 or 50%.